Hypoxia favors chemoresistance in T-ALL through an HIF1α-mediated mTORC1 inhibition loop

Resistance to chemotherapy, a major therapeutic challenge in the treatment of T-cell acute lymphoblastic leukemia (T-ALL), can be driven by interactions between leukemic cells and the microenvironment that promote survival of leukemic cells. The bone marrow, an important leukemia niche, has low oxyg...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Fahy, Lucine, Calvo, Julien, Chabi, Sara, Renou, Laurent, Le Maout, Charly, Poglio, Sandrine, Leblanc, Thierry, Petit, Arnaud, Baruchel, André, Ballerini, Paola, Naguibneva, Irina, Haddad, Rima, Arcangeli, Marie-Laure, Mazurier, Frederic, Pflumio, Francoise, Uzan, Benjamin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2021
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839374/
https://ncbi.nlm.nih.gov/pubmed/33496749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002832
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