DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes

Dihydroorotate dehydrogenase (DHODH) catalyzes a rate-limiting step in de novo pyrimidine nucleotide synthesis. DHODH inhibition has recently been recognized as a potential new approach for treating acute myeloid leukemia (AML) by inducing differentiation. We investigated the efficacy of PTC299, a n...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Kayamori, Kensuke, Nagai, Yurie, Zhong, Cheng, Kaito, Satoshi, Shinoda, Daisuke, Koide, Shuhei, Kuribayashi, Wakako, Oshima, Motohiko, Nakajima-Takagi, Yaeko, Yamashita, Masayuki, Mimura, Naoya, Becker, Hans Jiro, Izawa, Kiyoko, Yamazaki, Satoshi, Iwano, Satoshi, Miyawaki, Atsushi, Ito, Ryoji, Tohyama, Kaoru, Lennox, William, Sheedy, Josephine, Weetall, Marla, Sakaida, Emiko, Yokote, Koutaro, Iwama, Atsushi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2021
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839369/
https://ncbi.nlm.nih.gov/pubmed/33496740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001461
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi