The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells

The novel small molecule PTC596 inhibits microtubule polymerization and its clinical development has been initiated for some solid cancers. We herein investigated the preclinical efficacy of PTC596 alone and in combination with proteasome inhibitors in the treatment of multiple myeloma (MM). PTC596...

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Publié dans:Sci Rep
Auteurs principaux: Nagai, Yurie, Mimura, Naoya, Rizq, Ola, Isshiki, Yusuke, Oshima, Motohiko, Rizk, Mohamed, Saraya, Atsunori, Koide, Shuhei, Nakajima-Takagi, Yaeko, Miyota, Makiko, Chiba, Tetsuhiro, Oshima-Hasegawa, Nagisa, Muto, Tomoya, Tsukamoto, Shokichi, Mitsukawa, Shio, Takeda, Yusuke, Ohwada, Chikako, Takeuchi, Masahiro, Iseki, Tohru, Nakaseko, Chiaki, Lennox, William, Sheedy, Josephine, Weetall, Marla, Yokote, Koutaro, Iwama, Atsushi, Sakaida, Emiko
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822878/
https://ncbi.nlm.nih.gov/pubmed/33483574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81577-x
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