The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells

The novel small molecule PTC596 inhibits microtubule polymerization and its clinical development has been initiated for some solid cancers. We herein investigated the preclinical efficacy of PTC596 alone and in combination with proteasome inhibitors in the treatment of multiple myeloma (MM). PTC596...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Sci Rep
المؤلفون الرئيسيون: Nagai, Yurie, Mimura, Naoya, Rizq, Ola, Isshiki, Yusuke, Oshima, Motohiko, Rizk, Mohamed, Saraya, Atsunori, Koide, Shuhei, Nakajima-Takagi, Yaeko, Miyota, Makiko, Chiba, Tetsuhiro, Oshima-Hasegawa, Nagisa, Muto, Tomoya, Tsukamoto, Shokichi, Mitsukawa, Shio, Takeda, Yusuke, Ohwada, Chikako, Takeuchi, Masahiro, Iseki, Tohru, Nakaseko, Chiaki, Lennox, William, Sheedy, Josephine, Weetall, Marla, Yokote, Koutaro, Iwama, Atsushi, Sakaida, Emiko
التنسيق: Artigo
اللغة:Inglês
منشور في: Nature Publishing Group UK 2021
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822878/
https://ncbi.nlm.nih.gov/pubmed/33483574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81577-x
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