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Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability
INTRODUCTION: Translesion synthesis (TLS) is a DNA damage tolerance (DDT) mechanism that employs error-prone polymerases to bypass replication blocking DNA lesions, contributing to a gain in mutagenesis and chemo-resistance. However, recent findings illustrate an emerging role for TLS in replication...
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| Publicado no: | Expert Opin Ther Targets |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7837368/ https://ncbi.nlm.nih.gov/pubmed/33416413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14728222.2021.1864321 |
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