Replication Gaps Underlie BRCA-deficiency and Therapy Response

Defects in DNA repair and the protection of stalled DNA replication forks are thought to underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes BRCA1 and BRCA2 (BRCA). Challenging this assumption are recent findings that indicate chemotherapies such as cisplatin used...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Panzarino, Nicholas J., Krais, John J., Cong, Ke, Peng, Min, Mosqueda, Michelle, Nayak, Sumeet U., Bond, Samuel M., Calvo, Jennifer A., Doshi, Mihir B., Bere, Matt, Ou, Jianhong, Deng, Bin, Zhu, Lihua J., Johnson, Neil, Cantor, Sharon B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026497/
https://ncbi.nlm.nih.gov/pubmed/33184108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1602
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