ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

The small molecule ISRIB antagonizes the activation of the integrated stress response (ISR) by phosphorylated translation initiation factor 2, eIF2(αP). ISRIB and eIF2(αP) bind distinct sites in their common target, eIF2B, a guanine nucleotide exchange factor for eIF2. We have found that ISRIB-media...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Mol Cell
Main Authors: Zyryanova, Alisa F., Kashiwagi, Kazuhiro, Rato, Claudia, Harding, Heather P., Crespillo-Casado, Ana, Perera, Luke A., Sakamoto, Ayako, Nishimoto, Madoka, Yonemochi, Mayumi, Shirouzu, Mikako, Ito, Takuhiro, Ron, David
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cell Press 2021
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7837216/
https://ncbi.nlm.nih.gov/pubmed/33220178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.031
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla