Cell-free DNA tissues of origin by methylation profiling reveals significant cell, tissue, and organ-specific injury related to COVID-19 severity

BACKGROUND: Coronavirus disease 2019 (COVID-19) primarily affects the lungs, but evidence of systemic disease with multi-organ involvement is emerging. Here, we developed a blood test to broadly quantify cell-, tissue-, and organ-specific injury due to COVID-19. METHODS: Our test leverages genome-wi...

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Detalhes bibliográficos
Publicado no:Med (N Y)
Main Authors: Cheng, Alexandre Pellan, Cheng, Matthew Pellan, Gu, Wei, Sesing Lenz, Joan, Hsu, Elaine, Schurr, Erwin, Bourque, Guillaume, Bourgey, Mathieu, Ritz, Jerome, Marty, Francisco M., Chiu, Charles Y., Vinh, Donald C., De Vlaminck, Iwijn
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2021
Assuntos:
Clinical and Translational Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7836424/
https://ncbi.nlm.nih.gov/pubmed/33521749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.medj.2021.01.001
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