The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera

The current COVID-19 (coronavirus disease 19) pandemic, caused by SARS-CoV-2, disproportionally affects the elderly and people with comorbidities like obesity and associated type 2 diabetes mellitus. Small animal models are crucial for the successful development and validation of antiviral vaccines,...

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Publicado en:medRxiv
Main Authors: Rathnasinghe, Raveen, Jangra, Sonia, Cupic, Anastasija, Martínez-Romero, Carles, Mulder, Lubbertus C.F., Kehrer, Thomas, Yildiz, Soner, Choi, Angela, Mena, Ignacio, De Vrieze, Jana, Aslam, Sadaf, Stadlbauer, Daniel, Meekins, David A., McDowell, Chester D., Balaraman, Velmurugan, Richt, Juergen A., De Geest, Bruno G., Miorin, Lisa, Krammer, Florian, Simon, Viviana, García-Sastre, Adolfo, Schotsaert, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7836140/
https://ncbi.nlm.nih.gov/pubmed/33501468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.19.21249592
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