The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera

The current COVID-19 (coronavirus disease 19) pandemic, caused by SARS-CoV-2, disproportionally affects the elderly and people with comorbidities like obesity and associated type 2 diabetes mellitus. Small animal models are crucial for the successful development and validation of antiviral vaccines,...

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Vydáno v:medRxiv
Hlavní autoři: Rathnasinghe, Raveen, Jangra, Sonia, Cupic, Anastasija, Martínez-Romero, Carles, Mulder, Lubbertus C.F., Kehrer, Thomas, Yildiz, Soner, Choi, Angela, Mena, Ignacio, De Vrieze, Jana, Aslam, Sadaf, Stadlbauer, Daniel, Meekins, David A., McDowell, Chester D., Balaraman, Velmurugan, Richt, Juergen A., De Geest, Bruno G., Miorin, Lisa, Krammer, Florian, Simon, Viviana, García-Sastre, Adolfo, Schotsaert, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7836140/
https://ncbi.nlm.nih.gov/pubmed/33501468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.19.21249592
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