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Cellular Redox State Acts as Switch to Determine the Direction of NNT-Catalyzed Reaction in Cystic Fibrosis Cells

The redox states of NAD and NADP are linked to each other in the mitochondria thanks to the enzyme nicotinamide nucleotide transhydrogenase (NNT) which, by utilizing the mitochondrial membrane potential (mΔΨ), catalyzes the transfer of redox potential between these two coenzymes, reducing one at the...

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Pubblicato in:Int J Mol Sci
Autori principali: Favia, Maria, Atlante, Anna
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835933/
https://ncbi.nlm.nih.gov/pubmed/33478087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020967
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