Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies

Remdesivir (RDV) is a phosphoramidate prodrug designed to have activity against a broad spectrum of viruses. Following IV administration, RDV is rapidly distributed into cells and tissues and simultaneously metabolized into GS-441524 and GS-704277 in plasma. LC-MS/MS methods were validated for deter...

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Detalhes bibliográficos
Publicado no:Anal Biochem
Main Authors: Xiao, Deqing, John Ling, Kah Hiing, Tarnowski, Thomas, Humeniuk, Rita, German, Polina, Mathias, Anita, Chu, Jasper, Chen, Yuan-Shek, van Ingen, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835612/
https://ncbi.nlm.nih.gov/pubmed/33508271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2021.114118
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