Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies

Remdesivir (RDV) is a phosphoramidate prodrug designed to have activity against a broad spectrum of viruses. Following IV administration, RDV is rapidly distributed into cells and tissues and simultaneously metabolized into GS-441524 and GS-704277 in plasma. LC-MS/MS methods were validated for deter...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Anal Biochem
Autores principales: Xiao, Deqing, John Ling, Kah Hiing, Tarnowski, Thomas, Humeniuk, Rita, German, Polina, Mathias, Anita, Chu, Jasper, Chen, Yuan-Shek, van Ingen, Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835612/
https://ncbi.nlm.nih.gov/pubmed/33508271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2021.114118
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares