Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model

Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes: CCM1 (KRIT1), CCM2 (OSM), or CCM3 (PDCD10). Here...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Zhou, Huanjiao Jenny, Qin, Lingfeng, Jiang, Quan, Murray, Katie N., Zhang, Haifeng, Li, Busu, Lin, Qun, Graham, Morven, Liu, Xinran, Grutzendler, Jaime, Min, Wang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835246/
https://ncbi.nlm.nih.gov/pubmed/33495460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20774-0
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