Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model

Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes: CCM1 (KRIT1), CCM2 (OSM), or CCM3 (PDCD10). Here...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Zhou, Huanjiao Jenny, Qin, Lingfeng, Jiang, Quan, Murray, Katie N., Zhang, Haifeng, Li, Busu, Lin, Qun, Graham, Morven, Liu, Xinran, Grutzendler, Jaime, Min, Wang
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835246/
https://ncbi.nlm.nih.gov/pubmed/33495460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20774-0
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires