Augmented endothelial exocytosis of angiopoietin-2 resulting from CCM3-deficiency contributes to the progression of cerebral cavernous malformation

Cerebral cavernous malformations (CCMs) are vascular malformations that affect the central nervous system and result in cerebral hemorrhage, seizure and stroke. CCM arises from loss-of-function mutations in one of three genes: CCM1, CCM2 and CCM3 (PDCD10). CCM3 mutations in human often result in a m...

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Publicado no:Nat Med
Main Authors: Jenny Zhou, Huanjiao, Qin, Lingfeng, Zhang, Haifeng, Tang, Wenwen, Ji, Weidong, He, Yun, Liang, Xiaoling, Wang, Zongren, Yuan, Qianying, Vortmeyer, Alexander, Toomre, Derek, Fuh, Germaine, Yan, Minghong, Kluger, Martin S., Wu, Dianqing, Min, Wang
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014607/
https://ncbi.nlm.nih.gov/pubmed/27548575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4169
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