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Identification of a novel and potent small molecule inhibitor of SRPK1: mechanism of dual inhibition of SRPK1 for the inhibition of cancer progression

Protein kinases are the family of attractive enzyme targets for drug design with relevance to cancer biology. Serine arginine protein kinase 1 (SRPK1) is responsible for the phosphorylation of serine/arginine (SR)-rich proteins. Alternative Splicing Factor/Splicing Factor 2 (ASF/SF2) involved in mRN...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Chandra, Anshuman, Ananda, Hanumappa, Singh, Nagendra, Qamar, Imteyaz
Format: Artigo
Language:Inglês
Published: Impact Journals 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835025/
https://ncbi.nlm.nih.gov/pubmed/33291073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202301
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