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Translesion Synthesis Inhibitors as a New Class of Cancer Chemotherapeutics
INTRODUCTION: Translesion synthesis (TLS) is a DNA damage tolerance mechanism that replaces the replicative DNA polymerase with a specialized, low-fidelity TLS DNA polymerase that can copy past DNA lesions during active replication. Recent studies have demonstrated a primary role for TLS in replicat...
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| Udgivet i: | Expert Opin Investig Drugs |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7832080/ https://ncbi.nlm.nih.gov/pubmed/33179552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13543784.2021.1850692 |
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