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Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction
HIV reverse transcriptases (RTs) convert viral genomic RNA into double-stranded DNA. During reverse transcription, polypurine tracts (PPTs) resilient to RNase H cleavage are used as primers for plus-strand DNA synthesis. Nonnucleoside RT inhibitors (NNRTIs) can interfere with the initiation of plus-...
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| Veröffentlicht in: | Viruses |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7831940/ https://ncbi.nlm.nih.gov/pubmed/33477685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v13010131 |
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