Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis

Asp(443) and Glu(478) are essential active site residues in the RNase H domain of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). We have investigated the effects of substituting Asn for Asp(443) or Gln for Glu(478) on the fidelity of DNA-dependent DNA synthesis of phylogenet...

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Bibliografiska uppgifter
Huvudupphovsmän: Álvarez, Mar, Barrioluengo, Verónica, Afonso-Lehmann, Raquel N., Menéndez-Arias, Luis
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2013
Ämnen:
Nucleic Acid Enzymes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632107/
https://ncbi.nlm.nih.gov/pubmed/23444139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt109
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