The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform

Variants of the SH3 and multiple ankyrin repeat domains 3 (SHANK3), which encodes postsynaptic scaffolds, are associated with brain disorders. The targeted alleles in a few Shank3 knock-out (KO) lines contain a neomycin resistance (Neo) cassette, which may perturb the normal expression of neighborin...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Jin, Chunmei, Kang, Hyojin, Yoo, Taesun, Ryu, Jae Ryun, Yoo, Ye-Eun, Ma, Ruiying, Zhang, Yinhua, Kang, Hyae Rim, Kim, Yoonhee, Seong, Hyunyoung, Bang, Geul, Park, Sangwoo, Kwon, Seok-Kyu, Sun, Woong, Kim, Hyunkyung, Kim, Jin Young, Kim, Eunjoon, Han, Kihoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7831789/
https://ncbi.nlm.nih.gov/pubmed/33505245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.614435
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