Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium

Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of methotrexate (MTX), a highly lipophilic and p...

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Bibliografiske detaljer
Udgivet i:Pharmaceutics
Main Authors: Giri, Bhupendra Raj, Kim, Jung Suk, Park, Jong Hyuck, Jin, Sung Giu, Kim, Kyeong Soo, Din, Fakhar ud, Choi, Han Gon, Kim, Dong Wuk
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830624/
https://ncbi.nlm.nih.gov/pubmed/33467157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13010111
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