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A Case Report of Germline Compound Heterozygous Mutations in the BRCA1 Gene of an Ovarian and Breast Cancer Patient

The germline carrier of the BRCA1 pathogenic mutation has been well proven to confer an increased risk of breast and ovarian cancer. Despite BRCA1 biallelic pathogenic mutations being extremely rare, they have been reported to be embryonically lethal or to cause Fanconi anemia (FA). Here we describe...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Kwong, Ava, Ho, Cecilia Y. S., Shin, Vivian Y., Au, Chun Hang, Chan, Tsun Leung, Ma, Edmond S. K.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830606/
https://ncbi.nlm.nih.gov/pubmed/33477375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020889
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