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Overcoming Hypoxia-Induced Chemoresistance in Cancer Using a Novel Glycoconjugate of Methotrexate

The oxygen and nutrient-deprived tumor microenvironment is considered a key mechanism responsible for cancer resistance to chemotherapy. Methotrexate (MTX) is a widely incorporated chemotherapeutic agent employed in the treatment of several malignancies. However, drug resistance and systemic toxicit...

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Foilsithe in:Pharmaceuticals (Basel)
Main Authors: Woźniak, Marta, Pastuch-Gawołek, Gabriela, Makuch, Sebastian, Wiśniewski, Jerzy, Ziółkowski, Piotr, Szeja, Wiesław, Krawczyk, Monika, Agrawal, Siddarth
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830245/
https://ncbi.nlm.nih.gov/pubmed/33374474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14010013
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