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PhenQE8, a Novel Ligand of the Human Telomeric Quadruplex †

A novel quadruplex ligand based on 1,10-phenanthroline and incorporating two guanyl hydrazone functionalities, PhenQE8, is reported herein. Synthetic access was gained in a two-step procedure with an overall yield of 61%. X-ray diffraction studies revealed that PhenQE8 can adopt an extended conforma...

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Publicat a:Int J Mol Sci
Autors principals: Gratal, Patricia B., Quero, Julia G., Pérez-Redondo, Adrián, Gándara, Zoila, Gude, Lourdes
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7828518/
https://ncbi.nlm.nih.gov/pubmed/33451070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020749
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