The harsh microenvironment in early breast cancer selects for a Warburg phenotype

The harsh microenvironment of ductal carcinoma in situ (DCIS) exerts strong evolutionary selection pressures on cancer cells. We hypothesize that the poor metabolic conditions near the ductal center foment the emergence of a Warburg Effect (WE) phenotype, wherein cells rapidly ferment glucose to lac...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Damaghi, Mehdi, West, Jeffrey, Robertson-Tessi, Mark, Xu, Liping, Ferrall-Fairbanks, Meghan C., Stewart, Paul A., Persi, Erez, Fridley, Brooke L., Altrock, Philipp M., Gatenby, Robert A., Sims, Peter A., Anderson, Alexander R. A., Gillies, Robert J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826394/
https://ncbi.nlm.nih.gov/pubmed/33452133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011342118
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