The harsh microenvironment in early breast cancer selects for a Warburg phenotype

The harsh microenvironment of ductal carcinoma in situ (DCIS) exerts strong evolutionary selection pressures on cancer cells. We hypothesize that the poor metabolic conditions near the ductal center foment the emergence of a Warburg Effect (WE) phenotype, wherein cells rapidly ferment glucose to lac...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Damaghi, Mehdi, West, Jeffrey, Robertson-Tessi, Mark, Xu, Liping, Ferrall-Fairbanks, Meghan C., Stewart, Paul A., Persi, Erez, Fridley, Brooke L., Altrock, Philipp M., Gatenby, Robert A., Sims, Peter A., Anderson, Alexander R. A., Gillies, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826394/
https://ncbi.nlm.nih.gov/pubmed/33452133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011342118
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