OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms

OCT4 is a fundamental component of the molecular circuitry governing pluripotency in vivo and in vitro. To determine how OCT4 establishes and protects the pluripotent lineage in the embryo, we used comparative single-cell transcriptomics and quantitative immunofluorescence on control and OCT4 null b...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Stirparo, Giuliano G., Kurowski, Agata, Yanagida, Ayaka, Bates, Lawrence E., Strawbridge, Stanley E., Hladkou, Siarhei, Stuart, Hannah T., Boroviak, Thorsten E., Silva, Jose C. R., Nichols, Jennifer
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826362/
https://ncbi.nlm.nih.gov/pubmed/33452132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008890118
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