Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer

Hepatitis C virus (HCV) is a major worldwide health burden, and a preventive vaccine is needed for global control or eradication of this virus. A substantial hurdle to an effective HCV vaccine is the high variability of the virus, leading to immune escape. The E1E2 glycoprotein complex contains cons...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Guest, Johnathan D., Wang, Ruixue, Elkholy, Khadija H., Chagas, Andrezza, Chao, Kinlin L., Cleveland, Thomas E., Kim, Young Chang, Keck, Zhen-Yong, Marin, Alexander, Yunus, Abdul S., Mariuzza, Roy A., Andrianov, Alexander K., Toth, Eric A., Foung, Steven K. H., Pierce, Brian G., Fuerst, Thomas R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826332/
https://ncbi.nlm.nih.gov/pubmed/33431677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015149118
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