Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing

Investigations of CRISPR gene knockout editing profiles have contributed to enhanced precision of editing outcomes. However, for homology-directed repair (HDR) in particular, the editing dynamics and patterns in clinically relevant cells, such as human iPSCs and primary T cells, are poorly understoo...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Fu, Ya-Wen, Dai, Xin-Yue, Wang, Wen-Tian, Yang, Zhi-Xue, Zhao, Juan-Juan, Zhang, Jian-Ping, Wen, Wei, Zhang, Feng, Oberg, Kerby C, Zhang, Lei, Cheng, Tao, Zhang, Xiao-Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826255/
https://ncbi.nlm.nih.gov/pubmed/33398341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1251
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