Catalpol-Induced AMPK Activation Alleviates Cisplatin-Induced Nephrotoxicity through the Mitochondrial-Dependent Pathway without Compromising Its Anticancer Properties

Nephrotoxicity is a common complication of cisplatin chemotherapy and, thus, limits the clinical application of cisplatin. In this work, the effects of catalpol (CAT), a bioactive ingredient extracted from Rehmannia glutinosa, on cisplatin-induced nephrotoxicity and antitumor efficacy were comprehen...

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Detalles Bibliográficos
Publicado en:Oxid Med Cell Longev
Main Authors: Zhang, Jiangnan, Zhao, Tingting, Wang, Changyuan, Meng, Qiang, Huo, Xiaokui, Wang, Chong, Sun, Pengyuan, Sun, Huijun, Ma, Xiaodong, Wu, Jingjing, Liu, Kexin
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826214/
https://ncbi.nlm.nih.gov/pubmed/33510841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/7467156
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