Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties

Cisplatin is an effective anticancer drug; however, cisplatin use often leads to nephrotoxicity, which limits its clinical effectiveness. In this study, we determined the effect of dichloroacetate, a novel anticancer agent, in a mouse model of cisplatin-induced AKI. Pretreatment with dichloroacetate...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Galgamuwa, Ramindhu, Hardy, Kristine, Dahlstrom, Jane E., Blackburn, Anneke C., Wium, Elize, Rooke, Melissa, Cappello, Jean Y., Tummala, Padmaja, Patel, Hardip R., Chuah, Aaron, Tian, Luyang, McMorrow, Linda, Board, Philip G., Theodoratos, Angelo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084882/
https://ncbi.nlm.nih.gov/pubmed/26961349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070827
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