Human SIRT1 Multispecificity Is Modulated by Active-Site Vicinity Substitutions during Natural Evolution

Many enzymes that catalyze protein post-translational modifications can specifically modify multiple target proteins. However, little is known regarding the molecular basis and evolution of multispecificity in these enzymes. Here, we used a combined bioinformatics and experimental approaches to inve...

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Publicat a:Mol Biol Evol
Autors principals: Hendler, Adi, Akiva, Eyal, Sandhu, Mahakaran, Goldberg, Dana, Arbely, Eyal, Jackson, Colin J, Aharoni, Amir
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Discoveries
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826192/
https://ncbi.nlm.nih.gov/pubmed/32956445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msaa244
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