Gabapentin and Duloxetine Prevent Oxaliplatin- and Paclitaxel-Induced Peripheral Neuropathy by Inhibiting Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Phosphorylation in Spinal Cords of Mice

Chemotherapy-induced peripheral neuropathy is a common factor in limiting therapy which can result in therapy cessation or dose reduction. Gabapentin, a calcium channel inhibitor, and duloxetine, a serotonin noradrenaline reuptake inhibitor, are used to treat a variety of pain conditions such as chr...

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Enregistré dans:
Détails bibliographiques
Publié dans:Pharmaceuticals (Basel)
Auteurs principaux: Kato, Natsuki, Tateishi, Keisuke, Tsubaki, Masanobu, Takeda, Tomoya, Matsumoto, Mikihiro, Tsurushima, Katsumasa, Ishizaka, Toshihiko, Nishida, Shozo
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7824557/
https://ncbi.nlm.nih.gov/pubmed/33396362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14010030
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