Trametinib suppresses chemotherapy-induced cold and mechanical allodynia via inhibition of extracellular-regulated protein kinase 1/2 activation

Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of some anti-cancer drugs and leads to discontinuation of chemotherapy and detrimental dose reductions, thereby affecting the quality of life of cancer patients. Currently, no treatment can effectively prevent or treat chemot...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Tsubaki, Masanobu, Takeda, Tomoya, Matsumoto, Mikihiro, Kato, Natsuki, Asano, Ryo-ta, Imano, Motohiro, Satou, Takao, Nishida, Shozo
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079147/
https://ncbi.nlm.nih.gov/pubmed/30094097
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