An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics

Population pharmacokinetic (PK) modeling has become a cornerstone of drug development and optimal patient dosing. This approach offers great benefits for datasets with sparse sampling, such as in pediatric patients, and can describe between-patient variability. While most current algorithms assume n...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Yamada, Walter M., Neely, Michael N., Bartroff, Jay, Bayard, David S., Burke, James V., van Guilder, Mike, Jelliffe, Roger W., Kryshchenko, Alona, Leary, Robert, Tatarinova, Tatiana, Schumitzky, Alan
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7823953/
https://ncbi.nlm.nih.gov/pubmed/33396749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13010042
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