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Accurate detection of outliers and subpopulations with Pmetrics, a non-parametric and parametric pharmacometric modeling and simulation package for R

INTRODUCTION: Non-parametric population modeling algorithms have a theoretical superiority over parametric methods to detect pharmacokinetic and pharmacodynamic sub-groups and outliers within a study population. METHODS: The authors created “Pmetrics”, a new Windows and Unix R software package that...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Neely, Michael, van Guilder, Michael, Yamada, Walter, Schumitzky, Alan, Jelliffe, Roger
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394880/
https://ncbi.nlm.nih.gov/pubmed/22722776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0b013e31825c4ba6
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