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The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans
Osteocalcin (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions. Like many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its activity. Here, we uncover O-glycosylation as a novel PTM present on mouse OCN and occurring on a sin...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7822592/ https://ncbi.nlm.nih.gov/pubmed/33284103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61174 |
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