SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

BACKGROUND: Sirtuin 6 (SIRT6) is a NAD(+)-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here, we so...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Becherini, Pamela, Caffa, Irene, Piacente, Francesco, Damonte, Patrizia, Vellone, Valerio G., Passalacqua, Mario, Benzi, Andrea, Bonfiglio, Tommaso, Reverberi, Daniele, Khalifa, Amr, Ghanem, Moustafa, Guijarro, Ana, Tagliafico, Luca, Sucameli, Marzia, Persia, Angelica, Monacelli, Fiammetta, Cea, Michele, Bruzzone, Santina, Ravera, Silvia, Nencioni, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821730/
https://ncbi.nlm.nih.gov/pubmed/33482921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-021-00240-1
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