Hemolysis inhibits humoral B-cell responses and modulates alloimmunization risk in patients with sickle cell disease

Red blood cell alloimmunization remains a barrier for safe and effective transfusions in sickle cell disease (SCD), but the associated risk factors remain largely unknown. Intravascular hemolysis, a hallmark of SCD, results in the release of heme with potent immunomodulatory activity, although its e...

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Publicado en:Blood
Autores principales: Pal, Mouli, Bao, Weili, Wang, Rikang, Liu, Yunfeng, An, Xiuli, Mitchell, William B., Lobo, Cheryl A., Minniti, Caterina, Shi, Patricia A., Manwani, Deepa, Yazdanbakhsh, Karina, Zhong, Hui
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2021
Materias:
Transfusion Medicine
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820872/
https://ncbi.nlm.nih.gov/pubmed/33152749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008511
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