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PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics

Identifying and interpreting pleiotropic loci is essential to understanding the shared etiology among diseases and complex traits. A common approach to mapping pleiotropic loci is to meta-analyze GWAS summary statistics across multiple traits. However, this strategy does not account for the complex...

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Dettagli Bibliografici
Pubblicato in:Am J Hum Genet
Autori principali: Lee, Cue Hyunkyu, Shi, Huwenbo, Pasaniuc, Bogdan, Eskin, Eleazar, Han, Buhm
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820744/
https://ncbi.nlm.nih.gov/pubmed/33352115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.11.017
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