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Conformational Ensembles of Antibodies Determine Their Hydrophobicity
A major challenge in the development of antibody biotherapeutics is their tendency to aggregate. One root cause for aggregation is exposure of hydrophobic surface regions to the solvent. Many current techniques predict the relative aggregation propensity of antibodies via precalculated scales for th...
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| Publicado en: | Biophys J |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7820740/ https://ncbi.nlm.nih.gov/pubmed/33220303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.11.010 |
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