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Potassium Glutamate and Glycine Betaine Induce Self-Assembly of the PCNA and β-Sliding Clamps

Sliding clamps are oligomeric ring-shaped proteins that increase the efficiency of DNA replication. The stability of the Escherichia coli β-clamp, a homodimer, is particularly remarkable. The dissociation equilibrium constant of the β-clamp is of the order of 10 pM in buffers of moderate ionic stren...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Purohit, Anirban, Douma, Lauren G., Bloom, Linda B., Levitus, Marcia
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820735/
https://ncbi.nlm.nih.gov/pubmed/33221249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.11.013
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