The Mechanical Properties of PCNA: Implications for the Loading and Function of a DNA Sliding Clamp

Sliding clamps are toroidal proteins that encircle DNA and act as mobile platforms for DNA replication and repair machinery. To be loaded onto DNA, the eukaryotic sliding clamp Proliferating Cell Nuclear Antigen (PCNA) must be splayed open at one of the subunit-subunit interfaces by the ATP-dependen...

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Detalhes bibliográficos
Main Authors: Adelman, Joshua L., Chodera, John D., Kuo, I-Feng W., Miller, Thomas F., Barsky, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884248/
https://ncbi.nlm.nih.gov/pubmed/20550919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.03.056
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