The Mechanical Properties of PCNA: Implications for the Loading and Function of a DNA Sliding Clamp

Sliding clamps are toroidal proteins that encircle DNA and act as mobile platforms for DNA replication and repair machinery. To be loaded onto DNA, the eukaryotic sliding clamp Proliferating Cell Nuclear Antigen (PCNA) must be splayed open at one of the subunit-subunit interfaces by the ATP-dependen...

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Autors principals: Adelman, Joshua L., Chodera, John D., Kuo, I-Feng W., Miller, Thomas F., Barsky, Daniel
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2010
Matèries:
Protein
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884248/
https://ncbi.nlm.nih.gov/pubmed/20550919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.03.056
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