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Probabilistic colocalization of genetic variants from complex and molecular traits: promise and limitations

Colocalization analysis has emerged as a powerful tool to uncover the overlapping of causal variants responsible for both molecular and complex disease phenotypes. The findings from colocalization analysis yield insights into the molecular pathways of complex diseases. In this paper, we conduct an i...

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Bibliografske podrobnosti
izdano v:Am J Hum Genet
Main Authors: Hukku, Abhay, Pividori, Milton, Luca, Francesca, Pique-Regi, Roger, Im, Hae Kyung, Wen, Xiaoquan
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820626/
https://ncbi.nlm.nih.gov/pubmed/33308443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.11.012
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