PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis

We propose a new computational framework, probabilistic transcriptome-wide association study (PTWAS), to investigate causal relationships between gene expressions and complex traits. PTWAS applies the established principles from instrumental variables analysis and takes advantage of probabilistic eQ...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Zhang, Yuhua, Quick, Corbin, Yu, Ketian, Barbeira, Alvaro, Luca, Francesca, Pique-Regi, Roger, Kyung Im, Hae, Wen, Xiaoquan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
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Method
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488550/
https://ncbi.nlm.nih.gov/pubmed/32912253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02026-y
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