Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces

Alkaptonuria (AKU) is characterised by increased circulating homogentisic acid and deposition of ochronotic pigment in collagen-rich connective tissues (ochronosis), stiffening the tissue. This process over many years leads to a painful and severe osteoarthropathy, particularly affecting the cartila...

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Detalhes bibliográficos
Publicado no:Calcif Tissue Int
Main Authors: Hughes, Juliette H., Keenan, Craig M., Sutherland, Hazel, Edwards, Henry R., Wilson, Peter J. M., Ranganath, Lakshminarayan R., Jarvis, Jonathan C., Bou-Gharios, George, Gallagher, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820185/
https://ncbi.nlm.nih.gov/pubmed/33057760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-020-00764-6
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