Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk

Leukocyte inflammatory responses require integrin cell-adhesion molecule signaling through spleen tyrosine kinase (Syk), a non-receptor kinase that binds directly to integrin β-chain cytoplasmic domains. Here, we developed a high-throughput screen to identify small molecule inhibitors of the Syk-int...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Bakthavatsalam, Deenadayalan, Craft, John W., Kazansky, Anna, Nguyen, Nghi, Bae, Goeun, Caivano, Amy R., Gundlach, C. William, Aslam, Asra, Ali, Safa, Gupta, Shashikant, Lin, Sophie Y., Parthiban, Hema D., Vanderslice, Peter, Stephan, Clifford C., Woodside, Darren G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819857/
https://ncbi.nlm.nih.gov/pubmed/33488575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.575085
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