Cardiac fibroblast proliferation rates and collagen expression mature early and are unaltered with advancing age

Cardiac fibrosis is a pathophysiologic hallmark of the aging heart, but little is known about how fibroblast proliferation and transcriptional programs change throughout the life span of the organism. Using EdU pulse labeling, we demonstrated that more than 50% of cardiac fibroblasts were actively p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Wu, Rimao, Ma, Feiyang, Tosevska, Anela, Farrell, Colin, Pellegrini, Matteo, Deb, Arjun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819745/
https://ncbi.nlm.nih.gov/pubmed/33180747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140628
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