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Cardiac fibroblast proliferation rates and collagen expression mature early and are unaltered with advancing age

Cardiac fibrosis is a pathophysiologic hallmark of the aging heart, but little is known about how fibroblast proliferation and transcriptional programs change throughout the life span of the organism. Using EdU pulse labeling, we demonstrated that more than 50% of cardiac fibroblasts were actively p...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Wu, Rimao, Ma, Feiyang, Tosevska, Anela, Farrell, Colin, Pellegrini, Matteo, Deb, Arjun
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819745/
https://ncbi.nlm.nih.gov/pubmed/33180747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140628
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