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Canine orosomucoid (alpha-1 acid glycoprotein) variants and their influence on drug plasma protein binding

Orosomucoid polymorphisms influence plasma drug binding in humans, however, canine variants and their effect on drug plasma protein binding has not yet been reported. In this study, the orosomucoid gene (ORM1) was sequenced in 100 dogs to identify the most common variant and its allele frequency det...

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Pubblicato in:J Vet Pharmacol Ther
Autori principali: Costa, Ana P., Court, Michael H., Villarino, Nicolas F., Burke, Neal S., Mealey, Katrina L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819641/
https://ncbi.nlm.nih.gov/pubmed/32744755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jvp.12899
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