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Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding
Drug binding to plasma proteins is routinely determined during drug development. Albumin polymorphisms c.1075G>T (p.Ala359Ser) and c.1422A>T (p.Glu474Asp) were previously shown to alter plasma protein binding of a drug candidate (D01-4582, 4-[1-[3-chloro-4-[N′-(2-methylphenyl)ureido]phenylacet...
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| Vydáno v: | Drug Metab Dispos |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744390/ https://ncbi.nlm.nih.gov/pubmed/31481400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.087304 |
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