Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. While ≈50% of patients with HCM carry a sarcomere gene mutation (sarcomere mutation-positive, HCM(SMP)), the genetic background is unknown in the other half of the patients (sarcomere mutation-negative, HCM(SMN)). Genotype-s...

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Publicado en:Circ Heart Fail
Autores principales: Schuldt, Maike, Pei, Jiayi, Harakalova, Magdalena, Dorsch, Larissa M., Schlossarek, Saskia, Mokry, Michal, Knol, Jaco C., Pham, Thang V., Schelfhorst, Tim, Piersma, Sander R., dos Remedios, Cris, Dalinghaus, Michiel, Michels, Michelle, Asselbergs, Folkert W., Moutin, Marie-Jo, Carrier, Lucie, Jimenez, Connie R., van der Velden, Jolanda, Kuster, Diederik W.D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2021
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819533/
https://ncbi.nlm.nih.gov/pubmed/33430602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.120.007022
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